Jota replaced Roberto Firmino in the starting line-up and vindicated his selection with two superb first-half strikes, clipping a shot over the goalkeeper before chesting the ball down and rifling a shot in at the near post.
Mohamed Salah and Sadio Mane added to the goal-fest with brilliant efforts early in the second half, before Jota completed his hat-trick with the visitors’ fifth with just 54 minutes on the clock.
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The rout secured Jurgen Klopp’s first victory as a manager on Italian soil and Liverpool’s biggest away win in the Champions League since 2018 as they consolidated top spot and took a giant stride towards the knockout phase ahead of Atalanta’s visit to Anfield in three weeks’ time.